Peritoneal Mesothelioma

If you have been diagnosed with Mesothelioma or Lung Cancer you could be entitled to significant compensation from both the Asbestos Trust Funds and asbestos product manufactures.

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Understanding Peritoneal Mesothelioma

If you have been diagnosed with Mesothelioma or Lung Cancer you could be entitled to significant compensation from both the Asbestos Trust Funds and asbestos product manufactures.

Contact us now for a FREE consultation.

Free Case Review

What Is Peritoneal Mesothelioma?

Peritoneal mesothelioma is an aggressive and also rare form of cancer. It affects the peritoneum, which is the protective lining of the abdominal cavity.  

This lining helps protect the organs within the abdomen, including the stomach, intestines, and liver. 

When asbestos fibers are breathed in or ingested, they can embed in the peritoneal lining, leading to inflammation and cellular changes that eventually result in cancerous growth.

Anatomy of the Peritoneum and Growth in the Body

The peritoneum is a double-layered membrane that surrounds the abdominal organs. 

  • It plays a role in protecting and supporting these organs while also facilitating the movement of the intestines.

  • The peritoneum also helps keep organs lubricated, enabling smooth movement within the abdomen.

  • When this lining becomes damaged, such as by asbestos exposure, it can lead to severe health consequences, including peritoneal mesothelioma.

How Asbestos Exposure Leads to Peritoneal Mesothelioma

Asbestos exposure is the main known cause of peritoneal mesothelioma. 

  • When inhaled or swallowed, fibers of asbestos can lodge in the peritoneum’s tissues.

  • Over time, these fibers cause inflammation and irritation, leading to genetic mutations in the affected cells.

  • These mutations disrupt normal cell division, causing uncontrolled growth that forms tumors and, eventually, cancer in the peritoneum.

Mesothelioma exists in three primary forms: pleural, peritoneal, and pericardial. 

Each of the types of cancer may cause symptoms that are unique and specific to it. 

  • Pleural Mesothelioma, which affects the lungs’ lining, is the most common form of mesothelioma.

  • Peritoneal Mesothelioma affects the abdominal lining, as described.

  • Pericardial Mesothelioma affects the heart’s lining, making it the rarest form of mesothelioma.

While all types share similar risk factors, each type targets a different part of the body and requires unique treatment approaches.

The primary cause of peritoneal mesothelioma is being exposed to asbestos. However, other factors may increase the risk:

  • Genetic Predispositions: Some may have a genetic susceptibility that makes them more vulnerable to developing mesothelioma after asbestos exposure.

  • Environmental Exposure: Living near areas where asbestos was mined or used can also increase the risk of developing the disease.

  • Secondary Contact: Individuals who were not directly exposed to asbestos at work but came into contact with fibers carried home on workers’ clothing are also at risk

Symptoms of Peritoneal Mesothelioma

Due to its subtle symptoms, peritoneal mesothelioma patients may have symptoms that are difficult to detect early on. 

Peritoneal mesothelioma may be challenging to differentiate from other illnesses, which is why seeing a mesothelioma specialist can be the best option. 

  • Patients may experience mild abdominal discomfort, bloating, and digestive issues, like changes in bowel movements.

  • These symptoms tend to be vague and can easily be attributed to less serious conditions, making early diagnosis difficult.

  • Many individuals may dismiss these early signs, thinking they are related to common stomach or gastrointestinal problems

As the disease progresses and worsens, malignant peritoneal mesothelioma symptoms tend to become more severe and noticeable. 

  • One of the hallmark signs of advanced peritoneal mesothelioma is intense abdominal pain, which can be persistent and debilitating.

  • Another common symptom is ascites, a condition where fluid builds up in the abdomen, causing visible swelling and discomfort.

  • Additionally, bowel obstructions may occur. These can end up leading to severe constipation, nausea, and vomiting. These advanced symptoms tend to be more indicative of mesothelioma and require prompt medical attention.

Due to the overlap of symptoms with other common conditions, peritoneal mesothelioma is often misdiagnosed. 

  • The early signs, such as abdominal pain and bloating, are frequently mistaken for irritable bowel syndrome (IBS), Crohn’s disease, or even ovarian cancer, which share similar gastrointestinal symptoms.

  • This can delay the correct diagnosis and treatment, leading to a more advanced stage of cancer when it is finally detected.

  • It is essential to consider a patient’s history of asbestos exposure when evaluating these symptoms to avoid misdiagnosis.

Awareness of the possible symptoms of peritoneal mesothelioma is crucial for early detection. 

The sooner the disease is identified, the more treatment options are available, and the better the chances of effective symptom management and improved quality of life. 

Since the disease often progresses silently, patients with a history of asbestos exposure should be vigilant and consult with their healthcare providers as soon as any abdominal discomfort or digestive issues arise. 

Early diagnosis can significantly impact prognosis and help care providers choose the best treatment combination given the specific situation to help ensure it’s as effective as possible. 

A History of Asbestos Warnings

In the late 1970s, companies using asbestos in their products or manufacturing processes were required to warn consumers and workers about the risk it posed. Many companies filed for bankruptcy and set aside money for those victims who went on to develop asbestos lung disease or cancer.

Asbestos was so prevalent in military applications that it is estimated more World War II and Korean War veterans died of asbestos-related diseases than died in both wars combined. Although asbestos is seldom used now, many more construction workers or those working in the trades are still exposed to asbestos when they work on buildings or homes built before 1975. 

After being exposed to asbestos, the latency period for asbestos-causing damage or cancer is 20-60 years. In other words, the asbestos fibers are in the body for decades before they finally cause any significant damage. Due to this long latency and because workers are still exposed to asbestos when remodeling older buildings, the number of people diagnosed with asbestos related diseases such as mesothelioma, has not significantly decreased. 

Diagnosis of Peritoneal Mesothelioma

The diagnosis of peritoneal mesothelioma often begins with a review of the patient’s medical history, particularly any history of asbestos exposure. 

Several diagnostic tools are used to confirm the diagnosis in cases of mesothelioma. 

Imaging tests are essential for detecting abnormalities in the abdomen. 

These scans can identify the presence of tumors, fluid accumulation, and other signs of mesothelioma. 

  • CT scans are often the first imaging method used because they provide detailed cross-sectional images of the abdomen.

  • At the same time, MRIs offer more clarity on soft tissue involvement.

  • PET scans are used to assess the spread of cancer and determine if it has affected nearby organs.

Blood tests for specific biomarkers, such as mesothelin and fibulin-3, are also crucial in diagnosing peritoneal mesothelioma. 

These blood markers can be elevated in individuals with mesothelioma, although they are not definitive on their own. 

However, a biopsy is considered the gold standard for diagnosis to confirm cancer and the cell type as well as other specifics used for treatment. 

When getting a biopsy, a tissue sample is taken from the affected area, either via laparoscopy or through a needle inserted into the abdomen, and examined under a microscope. This examination can confirm the presence of cancerous cells

Diagnosing peritoneal mesothelioma presents a challenge because of several factors. 

One of the primary difficulties is distinguishing mesothelioma from other abdominal diseases that share similar symptoms, like Crohn’s disease or ovarian cancer. 

The overlapping symptoms of abdominal discomfort, bloating, and digestive disturbances can lead to misdiagnosis, especially during the early stages. 

Additionally, the slow progression of peritoneal mesothelioma means that symptoms don’t often appear until the disease has advanced, making it harder to identify in the earlier, more treatable stages.

Staging determines the extent and spread of cancer within the body. In mesothelioma, staging is crucial for planning treatment and understanding the prognosis. 

Peritoneal mesothelioma staging is generally done using the TNM system, which evaluates the size of the tumor (T), the number of involved lymph nodes (N), and whether the cancer has spread to other parts of the body (M). 

Mesothelioma is usually classified into four stages:

  • Stage I: At this cancer stage, it’s localized to the peritoneum.

  • Stage II: Cancer’s spread to nearby organs.

  • Stage III: Cancer has reached distant abdominal organs or lymph nodes.

  • Stage IV: Cancer spreads to other areas of the body, such as the lungs or distant organs.

Staging directly influences treatment options and prognosis. 

Early-stage mesothelioma (Stage I and II) may be treated more aggressively with surgery, chemotherapy, or radiation. 

In contrast, the later stages (Stages III and IV) often involve palliative treatments that aim to manage symptoms and improve quality of life. 

The earlier the diagnosis, the more effective peritoneal mesothelioma treatment tends to be, emphasizing the importance of timely detection to improve life expectancy. 

Treatment Options for Peritoneal Mesothelioma

Surgical options are often the primary treatment option for patients with peritoneal mesothelioma, particularly when the disease is in the early stages. 

Following a peritoneal mesothelioma diagnosis, the goal of surgical intervention is to remove as much of the cancerous tissue as possible, a procedure known as cytoreductive surgery. 

This surgery aims to reduce the tumor burden, which can help with symptoms and improve the effectiveness of subsequent treatments like chemotherapy. During cytoreductive surgery, the surgeon may remove parts of the peritoneum, affected organs, and other surrounding tissues to ensure the removal of all visible tumors.

Hyperthermic intraperitoneal chemotherapy (HIPEC) is a particularly promising treatment option in combination with cytoreductive surgery. 

HIPEC involves giving heated chemotherapy directly into the abdominal cavity after the tumors have been removed. 

The heat boosts the effectiveness of the chemotherapy, which helps the drugs penetrate deeper into the peritoneum and target any remaining microscopic cancer cells. 

Studies have shown that HIPEC when used in conjunction with cytoreductive surgery, can significantly improve survival rates and is considered a life-extending option for patients with peritoneal mesothelioma.

Chemotherapy is a standard treatment for peritoneal mesothelioma, particularly when the cancer is not amenable to surgery or has spread beyond the abdominal cavity. 

  • Systemic chemotherapy is the administration of drugs that circulate throughout the body to target and reduce tumor growth.

  • Cisplatin and pemetrexed are common chemotherapy drugs used to treat mesothelioma. They have been shown to slow the growth of mesothelioma cells and improve overall survival.

  • Systemic chemotherapy is used in combination with surgery or radiation therapy to enhance the overall treatment effectiveness in many cases.

  • Intraperitoneal chemotherapy is another approach that directly targets the peritoneal cavity. In this method, chemotherapy drugs are administered directly into the abdomen, allowing higher concentrations of the drug to reach the cancer cells in the peritoneum. This approach has been shown to be more effective in reducing tumor size than systemic chemotherapy alone and is especially beneficial when tumors are localized within the peritoneal cavity.

Radiation therapy is typically used in limited cases and is generally considered when surgery or chemotherapy is not viable. 

Radiation therapy uses high-energy rays that can target and kill cancer cells. It may be used to reduce the size of tumors before surgery or to treat any remaining cancer cells after surgery.

 However, its application is generally more limited in peritoneal mesothelioma due to the risk of radiation affecting nearby organs, such as the intestines and liver, which are located in the abdomen. 

Radiation is most commonly used for palliative care, helping to manage symptoms like pain and bleeding rather than as a curative treatment.

In recent years, new treatments have been explored to improve patient outcomes for those with peritoneal mesothelioma. 

  • Immunotherapy is one of the most promising areas of research. Immunotherapy uses the body’s immune system to recognize and attack cancer cells.

  • Checkpoint inhibitors (e.g., pembrolizumab and nivolumab) are a class of immunotherapies that work by blocking proteins that prevent the immune system from attacking cancer cells.

    • These drugs have shown positive results in clinical trials for various cancers, including mesothelioma, and may play a key role in future treatments.

  • Gene therapy is another area of interest in mesothelioma research.

    • This treatment involves altering the genetic material of cancer cells to either stop growing or make them more susceptible to treatment.

    • Although gene therapy for mesothelioma is still in its experimental stages, it has a lot of potential to improve the outlook and outcomes of people with advanced disease.

    • Clinical trials are ongoing at mesothelioma cancer centers, and gene therapy may become a standard part of mesothelioma treatment in the future.

As treatment options for peritoneal mesothelioma continue to evolve, clinical trials play a critical role in advancing care. 

Participating in clinical trials gives patients access to the latest experimental treatments and can help further the development of more effective therapies. 

Clinical trials offer hope for better outcomes and contribute to the understanding of the disease and how it can be treated more effectively in the future.

Treating peritoneal mesothelioma requires a multidisciplinary approach. 

This means a strategy that includes a team of specialists working together to provide the best possible care. 

This team typically includes oncologists, surgeons, radiologists, and palliative care specialists, who collaborate to create a plan tailored to the patient’s needs. Leading the team may be peritoneal mesothelioma specialists. 

The involvement of support staff, such as dietitians, counselors, and physical therapists, is also crucial for managing the patient’s physical and emotional well-being during the treatment process. 

The multidisciplinary team, which includes peritoneal mesothelioma doctors, combines various treatment modalities and expert insights to maximize the effectiveness of the treatment plan, improve quality of life, and extend survival.

Prognosis and Survival Rates

The prognosis for peritoneal mesothelioma varies depending on several factors. 

These can include the stage of diagnosis, the patient’s overall health, and the effectiveness of the chosen treatments. 

  • Generally, peritoneal mesothelioma has a poor prognosis due to its aggressive nature and late detection.

  • The median survival rate for those diagnosed with peritoneal mesothelioma is typically around 1 to 2 years, though some patients may live longer with advanced treatments.

  • The stage of the disease greatly impacts survival rates at diagnosis. Patients diagnosed in early stages (I or II) have a better chance of survival, with some studies indicating survival rates of 5 years or more with aggressive treatments like surgery and HIPEC.

  • For patients diagnosed in later stages (III or IV), survival rates are much lower due to the cancer spreading to other organs and tissues.

Several factors also affect prognosis, including the patient’s overall health, age, and response to treatments. 

Early detection remains crucial for improving outcomes, as it allows for more aggressive treatment options that can extend survival.

Aggressive treatment approaches, such as Hyperthermic Intraperitoneal Chemotherapy (HIPEC) combined with cytoreductive surgery, have shown significant promise in improving prognosis. 

HIPEC, in particular, can extend survival rates by targeting microscopic cancer cells that remain in the abdominal cavity after surgery. 

For those who are candidates for this treatment, it offers the best opportunity for a prolonged life.

Beyond medical treatments, nutrition, supportive care, and patient resilience also play key roles in improving prognosis. 

Maintaining a healthy diet, managing pain, and having strong emotional and psychological support can help patients remain strong during treatment. The patient’s resilience—both physically and mentally—can significantly affect their response to treatment and overall quality of life.

Builders occasionally used spray-on asbestos and other applicators that were initially considered somewhat safer. However, most builders used chrysotile asbestos because it was cheaper and easier to use. This brittle, crumbly substance almost immediately breaks down and releases asbestos dust into the air, sometimes as workers handle it. A single, microscopic asbestos fiber could cause mesothelioma or another serious illness, like asbestosis.

Shipbuilders used even more asbestos. Many parts of a ship, such as boiler rooms, generate lots of heat. Other parts of a ship, like ammunition storage areas, are highly explosive. Until 1980, the U.S. Navy, like many private builders, used asbestos because it was cheap and effective, and they ignored the health risks.

When actor Steve McQueen was in the Navy in the 1940s, his superiors allegedly forced him to scrape asbestos off pipes on the ship. Mesothelioma killed him in 1980.

Prevention and Risk Reduction

The only known way to prevent peritoneal mesothelioma is asbestos exposure since it is the primary cause of the disease. 

  • Strict workplace safety regulations have been implemented to protect workers in industries that historically used asbestos, such as construction, shipbuilding, and manufacturing. 

  • These regulations include providing protective equipment, ensuring proper ventilation, and implementing safety protocols to limit asbestos exposure. 

  • Employers are required to adhere to these regulations to minimize the risk of exposure for their workers.

  • For homeowners and general contractors, renovating older buildings that may contain asbestos is also important. If asbestos is present in materials like insulation, flooring, or roofing, it is essential to hire a certified asbestos removal professional. 

  • Avoid disturbing asbestos-containing materials, as airborne fibers can easily be inhaled, increasing the risk of exposure.

Education and awareness campaigns are vital for individuals who may be at risk of asbestos exposure. 

Targeted campaigns can help high-risk populations, such as construction workers and veterans, recognize the dangers of asbestos and take preventive measures. 

Additionally, spreading awareness about the importance of early detection and the potential link between asbestos exposure and mesothelioma can help those affected to make informed decisions about their health. 

Patient Support and Resources

Living with peritoneal mesothelioma can be incredibly challenging for both patients and their loved ones. Fortunately, several mesothelioma-specific support groups exist that offer a space for individuals to connect with others facing similar experiences. 

These support groups provide emotional support, information, and a sense of community. 

They can help patients cope with the psychological and emotional toll of the disease and offer guidance on managing the physical aspects of treatment.

In addition to support groups, counseling services are available to help patients and their families navigate and cope with the emotional challenges of mesothelioma. 

These services often include therapy for anxiety, depression, and grief, helping patients and caregivers address their mental health during this difficult time. 

Many community resources also assist with practical needs, such as transportation, financial aid, and caregiving support, which can ease the burden on families.

Getting treatment at a specialized mesothelioma treatment center is crucial for improving outcomes. 

These centers have the latest technology and are staffed by oncologists and surgeons who are experienced in treating mesothelioma. 

These experts can offer a comprehensive treatment plan that may include surgery, chemotherapy, and emerging therapies like immunotherapy.

To connect with the right medical professionals, patients should reach out to specialized centers and seek referrals to experienced mesothelioma oncologists and surgeons

Someone who receives a mesothelioma diagnosis has legal options and may seek compensation through mesothelioma litigation. Filing a claim against the responsible entity for your asbestos exposure may result in compensation for the costs. You could get compensation for the pain and suffering associated with asbestos illnesses. The following include some of the expenses you may be able to pursue compensation for:

FAQs About Peritoneal Mesothelioma

Peritoneal mesothelioma is primarily caused by asbestos exposure, a known carcinogen. 

When asbestos fibers are inhaled or ingested, they can then become trapped in the tissues of the peritoneum, leading to inflammation, cell damage, and, eventually, the development of cancer. One of the challenges with mesothelioma is its long latency period, meaning symptoms can take decades to appear after exposure. 

As a result, individuals who worked in industries where asbestos was prevalent—such as construction, shipbuilding, and manufacturing—are at higher risk, even many years after their exposure.

In the early stages, peritoneal mesothelioma can cause vague symptoms, making it difficult to diagnose. 

Common early symptoms include abdominal pain, bloating, and digestive discomfort (e.g., nausea or changes in bowel movements). 

These symptoms are often mistaken for less serious conditions like indigestion or irritable bowel syndrome (IBS), which can delay proper diagnosis and treatment.

Currently, there isn’t a cure for peritoneal mesothelioma. That said, treatment options such as surgery, chemotherapy, and radiation can help control the disease and improve quality of life. 

Curative treatments, like cytoreductive surgery combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), may offer extended survival for some patients if the disease is caught early. 

For later stages, palliative treatments are typically used to manage symptoms and improve comfort rather than to cure the disease

T

he diagnosis of peritoneal mesothelioma usually involves a combination of tests, such as CT scans, MRIs, and PET scans, which can reveal abnormalities in the abdominal cavity. 

A biopsy, where pathologists examine a sample of tissue to identify cancerous cells, is required to confirm the diagnosis. 

Advanced pathology techniques help differentiate mesothelioma from other conditions with symptoms that appear similar.

Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is a specialized treatment that involves delivering heated chemotherapy directly into the abdominal cavity after tumor removal surgery. 

The heat enhances the effectiveness of the chemo, allowing it to penetrate deeper into the peritoneum and target the remaining cancer cells. 

HIPEC improves survival rates and is often combined with cytoreductive surgery for patients diagnosed in earlier stages of peritoneal mesothelioma.

 

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